Eya3 Gene Summary [Mouse]
Enables chromatin binding activity; protein tyrosine phosphatase activity; and protein tyrosine/serine/threonine phosphatase activity. Acts upstream of or within protein dephosphorylation. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; genitourinary system; limb bud; rhombomere; and sensory organ. Orthologous to human EYA3 (EYA transcriptional coactivator and phosphatase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eya3 |
| Official Name | EYA transcriptional coactivator and phosphatase 3 [Source:MGI Symbol;Acc:MGI:109339] |
| Ensembl ID | ENSMUSG00000028886 |
| Bio databases IDs | |
| Aliases | EYA transcriptional coactivator and phosphatase 3 |
| Synonyms | EYA transcriptional coactivator and phosphatase 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eya3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein tyrosine/serine/threonine phosphatase
- protein-tyrosine-phoshatase
- protein phosphatase
- Pst domain
- phosphatase
- Eya domain
- chromatin binding
- enzyme
- protein binding
- Haloacid Dehalogenase-like Hydrolases
- Domain of unknown function (DUF3432)
- eyes absent protein conserved domain
Pathways
Biological processes and signaling networks where the Eya3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- renal clear cell adenocarcinoma
- renal clear cell cancer
- neoplastic cell transformation
role in cell
- cell viability
- phosphorylation in
- migration
- activation in
- apoptosis
- survival
- dephosphorylation in
- transcription in
- invasion
- modification in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- centrosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eya3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of DNA repair
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
- chromatin remodeling
- anatomical structure development
- cell differentiation
- anatomical structure morphogenesis
- visual perception
- double-strand break repair
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- protein tyrosine phosphatase activity