Six4 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of morphogenesis of an epithelium; regulation of DNA-templated transcription; and striated muscle cell differentiation. Acts upstream of or within several processes, including embryonic organ morphogenesis; myoblast migration; and thymus development. Located in cytoplasm and nucleus. Is expressed in several structures, including exocrine gland; genitourinary system; nervous system; sensory organ; and tongue. Orthologous to human SIX4 (SIX homeobox 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Six4 |
| Official Name | sine oculis-related homeobox 4 [Source:MGI Symbol;Acc:MGI:106034] |
| Ensembl ID | ENSMUSG00000034460 |
| Bio databases IDs | |
| Aliases | sine oculis-related homeobox 4 |
| Synonyms | AREC3, sine oculis-related homeobox 4, SIX homeobox 4, TrexBF |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Six4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- Transcriptional regulator, SIX1, N-terminal SD domain
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Six domain
- protein binding
- sequence-specific DNA binding
- homeodomain
- transcription factor activity
- DNA binding
Pathways
Biological processes and signaling networks where the Six4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- organismal death
- osteosarcoma
- osteosarcomagenesis
- non-insulin-dependent diabetes mellitus
- postnatal growth retardation
role in cell
- phosphorylation in
- apoptosis
- expression in
- proliferation
- growth
- differentiation
- cellular infiltration by
- migration
- organization
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Six4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male gonad development
- regulation of synaptic growth at neuromuscular junction
- fungiform papilla morphogenesis
- myotome development
- anatomical structure morphogenesis
- generation of neurons
- tongue development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of branch elongation involved in ureteric bud branching
- negative regulation of neuron apoptotic process
- thymus development
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- male sex differentiation
- positive regulation of ureteric bud formation
- regulation of epithelial cell proliferation
- protein localization to nucleus
- regulation of protein localization
- sarcomere organization
- embryonic cranial skeleton morphogenesis
- pharyngeal system development
- regulation of transcription from RNA polymerase II promoter
- olfactory placode formation
- positive regulation of branching involved in ureteric bud morphogenesis
- male sex determination
- metanephric mesenchyme development
- myoblast migration
- negative regulation of apoptotic process
- skeletal muscle tissue development
- inner ear morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity