Klhl7 Gene Summary [Mouse]
Predicted to enable protein homodimerization activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in several cellular components, including cytosol; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in cold-induced sweating syndrome 3 and retinitis pigmentosa 42. Orthologous to human KLHL7 (kelch like family member 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl7 |
| Official Name | kelch-like 7 [Source:MGI Symbol;Acc:MGI:1196453] |
| Ensembl ID | ENSMUSG00000028986 |
| Bio databases IDs | |
| Aliases | kelch-like 7 |
| Synonyms | 2700038B03Rik, CISS3, D5ERTD363E, kelch-like 7, kelch-like family member 7, KLHL6, PERCHING, SBBI26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein homodimerization
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- retinitis pigmentosa
- hepatocellular carcinoma
- liver cancer
- retinal dystrophy
- retinitis pigmentosa type 42
- cold-induced sweating syndrome 3
- Parkinson disease
- hereditary disorder
regulated by
- KLHL7
- sulforafan
role in cell
- colony formation
- degradation in
- cell viability
- ubiquitination in
- lenvatinib sensitivity
- K48 polyubiquitination in
- sorafenib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perinuclear region
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytosol
- Cul3-RING ubiquitin ligase complex
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity