Rasa2 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in intracellular signal transduction and negative regulation of Ras protein signal transduction. Predicted to be located in plasma membrane. Is expressed in brain and retina. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human RASA2 (RAS p21 protein activator 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rasa2 |
| Official Name | RAS p21 protein activator 2 [Source:MGI Symbol;Acc:MGI:2149960] |
| Ensembl ID | ENSMUSG00000032413 |
| Bio databases IDs | |
| Aliases | RAS p21 protein activator 2 |
| Synonyms | 5430433H21RIK, AU023900, GAP1M, RAS p21 protein activator 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rasa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ras GTPase Activating Domain
- GTPase-activator protein for Ras-like GTPases
- GTPase-activator protein for Ras-like GTPase
- BTK motif
- PH domain
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- allergy
- metabolic syndrome X
- breast carcinoma
- early missed abortion
- Noonan syndrome
- Noonan syndrome type 1
role in cell
- activation in
- proliferation
- growth
- killing
- phagocytosis by
- killing by
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rasa2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of Ras protein signal transduction
- signal transduction
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- GTPase activator activity
- phospholipid binding