Angptl7 Gene Summary [Mouse]
Predicted to enable identical protein binding activity. Predicted to be involved in negative regulation of vasculature development involved in avascular cornea development in camera-type eye and regulation of extracellular matrix organization. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in brain. Orthologous to human ANGPTL7 (angiopoietin like 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Angptl7 |
| Official Name | angiopoietin-like 7 [Source:MGI Symbol;Acc:MGI:3605801] |
| Ensembl ID | ENSMUSG00000028989 |
| Bio databases IDs | |
| Aliases | angiopoietin-like 7 |
| Synonyms | angiopoietin-like 7, AngX, CDT6, dJ647M16.1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Angptl7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- identical protein binding
- FReD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- metastasis
- neoplasia
- androgenic alopecia
- non-insulin-dependent diabetes mellitus
- open-angle glaucoma
- impaired insulin tolerance
- impaired glucose tolerance
- glaucoma
- alloxan-induced diabetic nephropathy
role in cell
- expression in
- number
- phosphorylation in
- organization
- degradation in
- vascular permeability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Bowman's membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Angptl7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding