Ints11 Gene Summary [Mouse]
Predicted to enable RNA endonuclease activity. Predicted to be involved in snRNA processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of integrator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities. Orthologous to human INTS11 (integrator complex subunit 11). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ints11 |
| Official Name | integrator complex subunit 11 [Source:MGI Symbol;Acc:MGI:1919207] |
| Ensembl ID | ENSMUSG00000029034 |
| Bio databases IDs | |
| Aliases | integrator complex subunit 11 |
| Synonyms | 2410006F12RIK, AI853843, CPSF3L, CPSF73L, INT11, integrator complex subunit 11, NEDMLOB, PSF3L, RC-68 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ints11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta-Casp domain
- endoribonuclease
- enzyme
- protein binding
- metallo-hydrolase-like_MBL-fold
- Zn-dependent metallo-hydrolase RNA specificity domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- ulcerative colitis
- neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities
- inflammatory bowel disease
role in cell
- expression in
- growth
- transcription in
- transcriptional pause release in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ints11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snRNA processing
- regulation of transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- blood microparticle
- cytosol
- nucleoplasm
- integrator complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- endoribonuclease activity