INTS11 Gene Summary [Human]
The Integrator complex contains at least 12 subunits and associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates the 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690). INTS11, or CPSF3L, is the catalytic subunit of the Integrator complex (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Details
| Type | Retained Intron |
| Official Symbol | INTS11 |
| Official Name | integrator complex subunit 11 [Source:HGNC Symbol;Acc:HGNC:26052] |
| Ensembl ID | ENSG00000127054 |
| Bio databases IDs | |
| Aliases | integrator complex subunit 11 |
| Synonyms | 2410006F12RIK, AI853843, CPSF3L, CPSF73L, INT11, integrator complex subunit 11, NEDMLOB, PSF3L, RC-68 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INTS11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta-Casp domain
- endoribonuclease
- enzyme
- protein binding
- metallo-hydrolase-like_MBL-fold
- Zn-dependent metallo-hydrolase RNA specificity domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Crohn disease
- ulcerative colitis
- neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities
- inflammatory bowel disease
role in cell
- expression in
- growth
- transcription in
- transcriptional pause release in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INTS11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snRNA processing
- regulation of transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- blood microparticle
- cytosol
- nucleoplasm
- integrator complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- endoribonuclease activity