Nrbp1 Gene Summary [Mouse]
Enables protein homodimerization activity. Involved in epithelial cell differentiation; epithelial cell proliferation; and in utero embryonic development. Located in perinuclear region of cytoplasm. Is expressed in cap mesenchyme; cerebellum; ovary; and renal interstitium. Orthologous to human NRBP1 (nuclear receptor binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nrbp1 |
| Official Name | nuclear receptor binding protein 1 [Source:MGI Symbol;Acc:MGI:2183436] |
| Ensembl ID | ENSMUSG00000029148 |
| Bio databases IDs | |
| Aliases | nuclear receptor binding protein 1 |
| Synonyms | B230344L17Rik, BCON3, MADM, MUDPNP, NRBP, nuclear receptor binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nrbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- protein kinase
- Protein Kinases, catalytic domain
- protein homodimerization
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- endomembrane system
- Cytoplasm
- perinuclear region
- Endoplasmic Reticulum
- membrane ruffles
- nucleoplasm
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nrbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cell cortex
- membrane
- endomembrane system
- lamellipodium
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein homodimerization activity
- protein serine/threonine kinase activity