Snx2 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol binding activity; protein dimerization activity; and signaling receptor binding activity. Predicted to be involved in early endosome to Golgi transport and lamellipodium morphogenesis. Located in membrane. Is expressed in embryo; neocortex; small intestine; and yolk sac. Orthologous to human SNX2 (sorting nexin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snx2 |
| Official Name | sorting nexin 2 [Source:MGI Symbol;Acc:MGI:1915054] |
| Ensembl ID | ENSMUSG00000034484 |
| Bio databases IDs | |
| Aliases | sorting nexin 2 |
| Synonyms | 0610030A03Rik, sorting nexin 2, TRG-9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- insulin receptor binding
- Vps5 C terminal like
- epidermal growth factor receptor binding
- Sorting nexin, N-terminal domain
- protein binding
- receptor binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- protein homodimerization
- The Phox Homology domain, a phosphoinositide binding module
- protein heterodimerization
- PX domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- exencephaly
- bleeding
role in cell
- formation
- recovery in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- vesicular element
- perinuclear region
- cellular membrane
- Nucleus
- vacuole
- endosomes
- vesicles
- lysosome
- cytoplasmic aggregates
- cytosol
- basolateral membrane
- endosomal membrane
- early endosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lamellipodium morphogenesis
- early endosome to Golgi transport
- retrograde transport, endosome to Golgi
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- endosome
- cytoplasm
- retromer complex, outer shell
- retromer complex
- membrane
- cytosol
- endosome membrane
- macromolecular complex
- lamellipodium
- lysosome
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- cadherin binding
- epidermal growth factor receptor binding
- phosphatidylinositol binding
- insulin receptor binding