Ssr1 Gene Summary [Mouse]
Located in endoplasmic reticulum. Is expressed in several structures, including bone; genitourinary system; pancreas; respiratory system; and tooth. Orthologous to human SSR1 (signal sequence receptor subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ssr1 |
| Official Name | signal sequence receptor, alpha [Source:MGI Symbol;Acc:MGI:105082] |
| Ensembl ID | ENSMUSG00000021427 |
| Bio databases IDs | |
| Aliases | signal sequence receptor, alpha |
| Synonyms | 2510001K09Rik, 6330400D04, Ac2-238, AI452176, signal sequence receptor, alpha, signal sequence receptor subunit 1, signal sequence receptor, α, Signal sequence receptor α subunit, SSR, SSR alpha, SSR α, Translocon associated protein α, TRAPA, Trap alpha, Trap α |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ssr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Translocon-associated protein (TRAP), alpha subunit
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- insomnia
- non-insulin-dependent diabetes mellitus
- vascular dementia
- major depression
- refractive error
- myopia
- productive infection by HIV-1
regulates
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ssr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cotranslational protein targeting to membrane
- positive regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding