Slc30a3 Gene Summary [Mouse]
Enables zinc ion transmembrane transporter activity. Involved in zinc ion import into synaptic vesicle. Acts upstream of or within positive regulation of transport. Located in hippocampal mossy fiber. Is active in several cellular components, including hippocampal mossy fiber to CA3 synapse; microvesicle; and synaptic vesicle membrane. Is expressed in several structures, including brain; metanephros; olfactory nerve; and spinal cord mantle layer. Orthologous to human SLC30A3 (solute carrier family 30 member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc30a3 |
| Official Name | solute carrier family 30 (zinc transporter), member 3 [Source:MGI Symbol;Acc:MGI:1345280] |
| Ensembl ID | ENSMUSG00000029151 |
| Bio databases IDs | |
| Aliases | solute carrier family 30 (zinc transporter), member 3 |
| Synonyms | solute carrier family 30 member 3, solute carrier family 30 (zinc transporter), member 3, ZNT3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc30a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cation diffusion facilitator family transporter
- protein binding
- zinc ion transporter
- Cation efflux family
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- cerebral amyloid angiopathy
- Alzheimer disease
role in cell
- morphology
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- glutaminergic synapse
- Cytoplasm
- microvesicles
- membrane surface
- synaptic membrane
- synaptic vesicles
- neurites
- synapse
- early endosomes
- late endosomes
- synaptic-like microvesicles
- axons
- dendrites
- mossy fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc30a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to zinc ion
- positive regulation of transport
- zinc ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- cytoplasm
- synaptic vesicle
- late endosome
- synaptic vesicle membrane
- neuron projection
- plasma membrane
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- antiporter activity
- metal ion binding
- zinc ion transmembrane transporter activity