Grin2b Gene Summary [Mouse]
Enables NMDA glutamate receptor activity and calcium channel activity. Involved in negative regulation of dendritic spine maintenance and regulation of synaptic plasticity. Acts upstream of or within several processes, including behavioral fear response; detection of mechanical stimulus involved in sensory perception of pain; and learning or memory. Located in several cellular components, including cytoplasmic vesicle; lysosome; and synaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including adipose tissue; central nervous system; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; neurodegenerative disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grin2b |
| Official Name | glutamate receptor, ionotropic, NMDA2B (epsilon 2) [Source:MGI Symbol;Acc:MGI:95821] |
| Ensembl ID | ENSMUSG00000030209 |
| Bio databases IDs | |
| Aliases | glutamate receptor, ionotropic, NMDA2B (epsilon 2) |
| Synonyms | AW490526, DEE27, EIEE27, GluN2B, GluR epsilon 2, GluR ε 2, glutamate ionotropic receptor NMDA type subunit 2B, glutamate receptor, ionotropic, NMDA2B (epsilon 2), glutamate receptor, ionotropic, NMDA2B (ε 2), hNR3, MRD6, NMDAR2B, NMDE2, NR2B, NR3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grin2b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-methyl D-aspartate receptor 2B3 C-terminus
- cell adhesion molecule binding
- G-protein-coupled receptor binding
- glutamate binding
- ion channel
- N-methyl-D-aspartate selective glutamate receptor
- zinc ion binding
- cytoplasmic domain
- glycine binding
- Type 1 periplasmic binding fold superfamily
- Type 2 periplasmic binding fold superfamily
- KKNXN motif
- tail domain
- Src phosphorylation site
- PXXP Class I motif
- Receptor family ligand binding region
- protein kinase binding
- calcium channel
- beta-catenin binding
- channel/pore class transporter
- Ligated ion channel L-glutamate- and glycine-binding site
- ionotropic glutamate receptor
- glutamate-gated ion channel
- extracellular ligand-gated ion channel
- protein binding
- receptor binding
- ionotropic glutamate receptor binding
- PSD 95 binding domain
- interleukin-1 receptor binding
- binding protein
- neurotransmitter receptor
- ligand-gated ion channel
- cytosolic tail domain
- PXXP motif
- PDZ binding motif
- cation channel
- Bacterial extracellular solute-binding proteins, family 3
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Grin2b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Calcium Signaling
- Circadian Rhythm Signaling
- CREB Signaling in Neurons
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Ephrin Receptor Signaling
- Glutamate Receptor Signaling
- Huntington's Disease Signaling
- Neuroinflammation Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- nNOS Signaling in Neurons
- Opioid Signaling Pathway
- Reelin Signaling in Neurons
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- alcoholism
- colorectal cancer
- metastasis
- dementia
- schizophrenia
- depressive disorder
- anxiety disorder
- amyotrophic lateral sclerosis
- essential tremor
- Huntington disease
regulated by
- HTT
- Ca2+
- (S)-3,5-dihydroxyphenylglycine
- beta-estradiol
- LY294002
- trans-flupentixol
- allopregnanolone
- PKC
- insulin
- kalirin
role in cell
- cell death
- apoptosis
- formation in
- expression in
- formation
- phosphorylation in
- activation in
- number
- production in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- soluble fraction
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- proximal axon
- cytoplasmic vesicle membrane
- organelle
- Cytoplasm
- cell surface
- postsynaptic region
- cellular membrane
- vesicles
- lysosome
- endoplasmic reticulum membrane
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- synaptic vesicles
- neurites
- synaptosomes
- synapse
- Z line
- late endosomes
- perikaryon
- dendrites
- postsynaptic density
- axon terminals
- excitatory synapses
- dendritic branches
- apical processes
- vesicle fraction
- synaptic vesicle fractions
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grin2b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of excitatory postsynaptic membrane potential
- synaptic transmission
- brain development
- protein heterotetramerization
- learning or memory
- glutamate receptor signaling pathway
- response to ethanol
- regulation of neuronal synaptic plasticity
- regulation of synaptic plasticity
- positive regulation of excitatory postsynaptic membrane potential
- long-term synaptic potentiation
- positive regulation of synaptic transmission, glutamatergic
- calcium-mediated signaling
- ionotropic glutamate receptor signaling pathway
- positive regulation of cysteine-type endopeptidase activity
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- late endosome
- synaptic membrane
- neuron projection
- plasma membrane
- cell surface
- lysosome
- endoplasmic reticulum membrane
- cytoskeleton
- postsynaptic membrane
- cytoplasm
- N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- glutamate-gated calcium ion channel activity
- glycine binding
- glutamate binding
- beta-amyloid binding
- N-methyl-D-aspartate selective glutamate receptor activity