Grin2a Gene Summary [Mouse]
Enables NMDA glutamate receptor activity and calcium channel activity. Involved in glutamate receptor signaling pathway and regulation of synaptic plasticity. Acts upstream of or within several processes, including excitatory postsynaptic potential; learning or memory; and long-term synaptic potentiation. Located in several cellular components, including cell surface; synaptic membrane; and synaptic vesicle. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including central nervous system; eye; hindlimb phalanx; intestine; and limb mesenchyme. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; bipolar disorder; colorectal cancer; and heroin dependence. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grin2a |
| Official Name | glutamate receptor, ionotropic, NMDA2A (epsilon 1) [Source:MGI Symbol;Acc:MGI:95820] |
| Ensembl ID | ENSMUSG00000059003 |
| Bio databases IDs | |
| Aliases | glutamate receptor, ionotropic, NMDA2A (epsilon 1) |
| Synonyms | AK080997, EPND, FESD, GluN2A, GluRepsilon1, Glur ε 1, glutamate ionotropic receptor NMDA type subunit 2A, glutamate receptor, ionotropic, NMDA2A (epsilon 1), glutamate receptor, ionotropic, NMDA2A (ε 1), LKS, NMDAR2A, NR2, NR2A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grin2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-methyl D-aspartate receptor 2B3 C-terminus
- cell adhesion molecule binding
- signal peptide
- glutamate binding
- ion channel
- N-methyl-D-aspartate selective glutamate receptor
- zinc ion binding
- cytoplasmic domain
- Type 1 periplasmic binding fold superfamily
- Type 2 periplasmic binding fold superfamily
- LIVBP-like domain
- tail domain
- calcium-dependent protein binding
- Receptor family ligand binding region
- protein kinase binding
- calcium channel
- channel/pore class transporter
- PXXP Class II motif
- Ligated ion channel L-glutamate- and glycine-binding site
- ionotropic glutamate receptor
- glutamate-gated ion channel
- extracellular ligand-gated ion channel
- protein binding
- receptor binding
- beta-amyloid binding
- PSD 95 binding domain
- ATPase binding
- binding protein
- neurotransmitter receptor
- ligand-gated ion channel
- cytosolic tail domain
- voltage-gated ion channel
- cation channel
- Bacterial extracellular solute-binding proteins, family 3
Pathways
Biological processes and signaling networks where the Grin2a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Calcium Signaling
- Circadian Rhythm Signaling
- CREB Signaling in Neurons
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Ephrin Receptor Signaling
- Glutamate Receptor Signaling
- Neuroinflammation Signaling Pathway
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- nNOS Signaling in Neurons
- Opioid Signaling Pathway
- Reelin Signaling in Neurons
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- breast cancer
- central nervous system tumor
- adult solid tumor
- major depression
- cognitive impairment
- multiple sclerosis
- moderate to severe Alzheimer disease
- hepatocellular carcinoma
- Landau Kleffner syndrome
role in cell
- phosphorylation in
- expression in
- apoptosis
- formation
- cell death
- growth
- transcription in
- organization
- depolarization
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- soluble fraction
- postsynaptic density (PSD) fractions
- detergent-insoluble fractions
- membrane fraction
- glutaminergic synapse
- organelle
- Cytoplasm
- cell surface
- postsynaptic region
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- synaptic vesicles
- neurites
- synaptosomes
- synapse
- membrane rafts
- perikaryon
- dendrites
- postsynaptic density
- axon terminals
- excitatory synapses
- dendritic shafts
- plasma
- vesicle fraction
- synaptic vesicle fractions
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grin2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dopamine metabolic process
- response to wounding
- negative regulation of protein catabolic process
- visual learning
- neurogenesis
- response to xenobiotic stimulus
- memory
- glutamate receptor signaling pathway
- learning or memory
- response to ethanol
- startle response
- activation of cysteine-type endopeptidase activity
- regulation of neuronal synaptic plasticity
- regulation of synaptic plasticity
- long-term synaptic potentiation
- directional locomotion
- positive regulation of synaptic transmission, glutamatergic
- ionotropic glutamate receptor signaling pathway
- calcium-mediated signaling
- regulation of excitatory postsynaptic membrane potential
- serotonin metabolic process
- protein catabolic process
- synaptic transmission
- brain development
- response to amphetamine
- positive regulation of apoptotic process
- sensory perception of pain
- sleep
- positive regulation of excitatory postsynaptic membrane potential
- synaptic transmission, glutamatergic
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- endoplasmic reticulum membrane
- postsynaptic density
- cytoplasmic vesicle membrane
- postsynaptic membrane
- synaptic vesicle
- dendritic spine
- synaptic membrane
- N-methyl-D-aspartate selective glutamate receptor complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- glutamate-gated calcium ion channel activity
- beta-amyloid binding
- N-methyl-D-aspartate selective glutamate receptor activity