Tmem165 Gene Summary [Mouse]
Predicted to enable calcium ion transmembrane transporter activity and manganese ion transmembrane transporter activity. Involved in calcium ion transport and manganese ion transport. Located in cis-Golgi network membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIk. Orthologous to human TMEM165 (transmembrane protein 165). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem165 |
| Official Name | transmembrane protein 165 [Source:MGI Symbol;Acc:MGI:894407] |
| Ensembl ID | ENSMUSG00000029234 |
| Bio databases IDs | |
| Aliases | transmembrane protein 165 |
| Synonyms | CDG2K, FT27, GDT1, LOC100911646, pFT27, SLC64A1, TM165, TMPT27, Tpardl, TPARL, transmembrane protein 165 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem165 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Uncharacterized protein family UPF0016
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type 2k
regulated by
- megakaryocytes
- BMP2
role in cell
- phosphorylation in
- expression in
- phagocytosis by
- pH regulation
- signaling in
- homeostasis in
- elongation in
- synthesis in
- mineralization
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cellular membrane
- Golgi Apparatus
- Mitochondria
- trans Golgi network
- lysosome membrane
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem165 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of lysosomal lumen pH
- manganese ion transport
- Golgi calcium ion transport
- manganese ion transmembrane transport
- calcium ion transport
- calcium ion transmembrane transport
- protein N-linked glycosylation
- Golgi calcium ion homeostasis
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- endosome membrane
- Golgi apparatus
- Golgi membrane
- trans-Golgi network membrane
- lysosomal membrane
- cis-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- antiporter activity
- calcium ion transmembrane transporter activity
- manganese ion transmembrane transporter activity