Brd8 Gene Summary [Mouse]
Predicted to enable nuclear thyroid hormone receptor binding activity and transcription coactivator activity. Predicted to be involved in cellular response to thyroid hormone stimulus; positive regulation of nucleobase-containing compound metabolic process; and regulation of cell cycle. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of NuA4 histone acetyltransferase complex; Swr1 complex; and nucleosome. Is expressed in early conceptus; ganglia; genitourinary system; heart; and limb mesenchyme. Orthologous to human BRD8 (bromodomain containing 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brd8 |
| Official Name | bromodomain containing 8 [Source:MGI Symbol;Acc:MGI:1925906] |
| Ensembl ID | ENSMUSG00000003778 |
| Bio databases IDs | |
| Aliases | bromodomain containing 8 |
| Synonyms | 2610007E11Rik, 4432404P07RIK, 4933408B17, 4933408B17Rik, bromodomain containing 8, p120, SMAP, SMAP2, THYROID HORMONE receptor COACTIVATING |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brd8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- protein binding
- thyroid hormone receptor binding
- Bromodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- primary hyperaldosteronism
role in cell
- cell viability
- transactivation in
- cell cycle progression
- differentiation
- homologous recombination repair in
- accumulation in
- dispersal in
- missegregation in
- dispersal
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- nucleosomes
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brd8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to thyroid hormone stimulus
- regulation of double-strand break repair
- positive regulation of transcription, DNA-dependent
- regulation of apoptotic process
- cell surface receptor signaling pathway
- regulation of cell cycle
- positive regulation of transcription from RNA polymerase II promoter
- chromatin organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- NuA4 histone acetyltransferase complex
- mitochondrion
- Swr1 complex
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ligand-dependent nuclear receptor transcription coactivator activity
- thyroid hormone receptor binding