Zscan21 Gene Summary [Mouse]
Enables DNA binding activity. Involved in male meiosis I and spermatogenesis. Acts upstream of or within positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut gland; liver and biliary system; and nervous system. Orthologous to human ZSCAN21 (zinc finger and SCAN domain containing 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zscan21 |
| Official Name | zinc finger and SCAN domain containing 21 [Source:MGI Symbol;Acc:MGI:99182] |
| Ensembl ID | ENSMUSG00000037017 |
| Bio databases IDs | |
| Aliases | zinc finger and SCAN domain containing 21 |
| Synonyms | CTfin51, NY-REN-21, NY-REN-21 antigen, RU49, ZFP38, zinc finger and SCAN domain containing 21, Zipro1, ZNF38 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zscan21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- leucine rich region
- zinc finger
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- Zinc-finger double domain
- SCAN domain
- protein binding
- sequence-specific DNA binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zscan21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- male meiosis I
- cell differentiation
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity