Ldhd Gene Summary [Mouse]
Predicted to enable D-lactate dehydrogenase (cytochrome) activity; D-lactate dehydrogenase activity; and flavin adenine dinucleotide binding activity. Predicted to be involved in lactate catabolic process. Located in mitochondrion. Orthologous to human LDHD (lactate dehydrogenase D). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ldhd |
| Official Name | lactate dehydrogenase D [Source:MGI Symbol;Acc:MGI:106428] |
| Ensembl ID | ENSMUSG00000031958 |
| Bio databases IDs | |
| Aliases | lactate dehydrogenase D |
| Synonyms | 4733401P21Rik, Ac2-202, D8BWG1320E, DLACD, DLD, lactate dehydrogenase D |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ldhd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding domain
- FAD linked oxidases, C-terminal domain
- glycolate oxidase, subunit GlcD
- D-lactate dehydrogenase (cytochrome)
- enzyme
- protein binding
- D-lactate dehydrogenase
Pathways
Biological processes and signaling networks where the Ldhd gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- lactic aciduria due to D-lactic acid
- D-lactic aciduria with gout
- renal clear cell adenocarcinoma
- renal clear cell cancer
- pervasive developmental disorder
- androgenic alopecia
regulates
- lactic acid
- pyruvic acid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ldhd gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- FAD binding
- D-lactate dehydrogenase (cytochrome) activity
- protein binding
- flavin adenine dinucleotide binding
- D-lactate dehydrogenase activity