Cnbp Gene Summary [Mouse]
Predicted to enable DNA binding activity; RNA binding activity; and translation regulator activity. Involved in positive regulation of DNA-templated transcription. Acts upstream of or within positive regulation of cell population proliferation and positive regulation of transcription by RNA polymerase II. Located in cytosol; endoplasmic reticulum; and nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; egg cylinder; and genitourinary system. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to human CNBP (CCHC-type zinc finger nucleic acid binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnbp |
| Official Name | cellular nucleic acid binding protein [Source:MGI Symbol;Acc:MGI:88431] |
| Ensembl ID | ENSMUSG00000030057 |
| Bio databases IDs | |
| Aliases | cellular nucleic acid binding protein |
| Synonyms | CCHC-type zinc finger nucleic acid binding protein, CCHC-type zinc finger, nucleic acid binding protein, Cellular Nucleic Acid Binding, cellular nucleic acid binding protein, CNBP1, DM2, Nabp, PROMM, RNF163, ZCCHC22, ZNF9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cnbp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- single-stranded DNA binding
- protein binding
- single-stranded RNA binding
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- myotonic dystrophy
- myotonic dystrophy type 2
role in cell
- polarization
- proliferation
- invasion by
- atrophy
- translation in
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- endoplasmic reticulum mitochondria contact site
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cnbp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of cytoplasmic translation
- positive regulation of transcription, DNA-dependent
- positive regulation of cell proliferation
- G-quadruplex DNA formation
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- translation regulator activity
- RNA binding
- protein binding
- G-quadruplex DNA binding
- single-stranded RNA binding
- mRNA binding