Ak1 Gene Summary [Mouse]
Enables adenylate kinase activity. Predicted to be involved in nucleobase-containing small molecule metabolic process and positive regulation of D-glucose transmembrane transport. Located in outer dense fiber. Is expressed in several structures, including heart; lung; metanephros; nervous system; and nose. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia; congenital nonspherocytic hemolytic anemia 3; and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ak1 |
| Official Name | adenylate kinase 1 [Source:MGI Symbol;Acc:MGI:87977] |
| Ensembl ID | ENSMUSG00000026817 |
| Bio databases IDs | |
| Aliases | adenylate kinase 1 |
| Synonyms | Adenylate kinase, ADENYLATE KINASE 1, ADK, Adk1, B430205N08Rik, CNSHA3, HTL-S-58j, Kad1, LOC108350550 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ak1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- nucleoside diphosphate kinase
- adenylate kinase
- phosphate group acceptor phosphotransferase
- NK
- adenylate kinase, isozyme 1 subfamily
- UMP-CMP kinase family
- N-terminal helicase domain of the DEAD-box helicase superfamily
- AAA domain
Pathways
Biological processes and signaling networks where the Ak1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- hemolytic anemia due to adenylate kinase deficiency
- deficiency of adenylate kinase
role in cell
- cell viability
- formation
- volume
- cell cycle progression
- coupling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Plasma Membrane
- sarcomere
- cytosol
- sperm tail
- outer dense fibers
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ak1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ADP biosynthetic process
- AMP metabolic process
- nucleoside triphosphate biosynthetic process
- nucleobase-containing small molecule interconversion
- ATP metabolic process
- nucleoside monophosphate phosphorylation
Cellular Component
Where in the cell the gene product is active
- outer dense fiber
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- adenylate kinase activity
- nucleoside diphosphate kinase activity
- nucleoside triphosphate adenylate kinase activity