Slc6a13 Gene Summary [Mouse]
Enables gamma-aminobutyric acid:sodium:chloride symporter activity and taurine:sodium symporter activity. Involved in taurine transmembrane transport. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and liver and biliary system. Orthologous to human SLC6A13 (solute carrier family 6 member 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc6a13 |
| Official Name | solute carrier family 6 (neurotransmitter transporter, GABA), member 13 [Source:MGI Symbol;Acc:MGI:95629] |
| Ensembl ID | ENSMUSG00000030108 |
| Bio databases IDs | |
| Aliases | solute carrier family 6 (neurotransmitter transporter, GABA), member 13 |
| Synonyms | Gabt3, GAT-2, GAT3, solute carrier family 6 member 13, solute carrier family 6 (neurotransmitter transporter, GABA), member 13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc6a13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium:neurotransmitter symporter family
- taurine transporter
- taurine:sodium symporter
- sodium:amino acid transporter
- gamma-aminobutyrate transporter
- protein binding
- monocarboxylic acid transporter
- GABA:sodium symporter
- amino acid binding
- Solute carrier families 5 and 6-like; solute binding domain
- amino acid transporter
- transporter
- creatine transporter
Pathways
Biological processes and signaling networks where the Slc6a13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anxiety disorder
- generalized anxiety disorder
- social anxiety disorder
- partial seizure
- epithelial cancer
- epilepsy
- chronic kidney disease
- kidney carcinoma
- renal cancer
- IgA nephropathy
regulates
- neurotransmitter
- GABA
- beta-alanine
- creatine
- IgA
- MTOR
- taurine
- monocarboxylic acid
role in cell
- number
- phosphorylation in
- quantity
- frequency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc6a13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nitrogen compound transport
- creatine transport
- gamma-aminobutyric acid import
- monocarboxylic acid transport
- gamma-aminobutyric acid uptake involved in synaptic transmission
- sodium ion transmembrane transport
- amino acid transport
- taurine transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- basolateral plasma membrane
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- creatine transporter activity
- sodium:amino acid symporter activity
- L-gamma-aminobutyric acid transmembrane transporter activity
- gamma-aminobutyric acid:sodium symporter activity
- amino acid transmembrane transporter activity
- taurine:sodium symporter activity
- monocarboxylic acid transmembrane transporter activity
- taurine transmembrane transporter activity