Plekha5 Gene Summary [Mouse]
Enables phosphatidylinositol phosphate binding activity. Acts upstream of or within reproductive system development. Located in cytosol. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including brain; ganglia; gonad; metanephros; and trigeminal nerve. Orthologous to human PLEKHA5 (pleckstrin homology domain containing A5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekha5 |
| Official Name | pleckstrin homology domain containing, family A member 5 [Source:MGI Symbol;Acc:MGI:1923802] |
| Ensembl ID | ENSMUSG00000030231 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family A member 5 |
| Synonyms | 2810431N21Rik, AMH-Cre, Ayu21-9, Gt(pU21)9Imeg, Image:3710928, PEPP-2, PKHA5, pleckstrin homology domain containing A5, pleckstrin homology domain containing, family A member 5, Tg(AMH-cre)1Flor, TRS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekha5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain with 2 conserved Trp (W) residues
- binding protein
- WW
- PH domain
- protein binding
- Pleckstrin homology-like domain
- WW domain
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytosol
- nucleoplasm
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekha5 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- protein binding
- phosphatidylinositol-5-phosphate binding
- phosphatidylinositol-3,5-bisphosphate binding
- phosphatidylinositol-3-phosphate binding