Pde3b Gene Summary [Mouse]
Enables 3',5'-cyclic-AMP phosphodiesterase activity and protein kinase B binding activity. Involved in cellular response to insulin stimulus. Acts upstream of or within endocrine pancreas development; glucose homeostasis; and regulation of insulin secretion. Located in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human PDE3B (phosphodiesterase 3B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pde3b |
| Official Name | phosphodiesterase 3B, cGMP-inhibited [Source:MGI Symbol;Acc:MGI:1333863] |
| Ensembl ID | ENSMUSG00000030671 |
| Bio databases IDs | |
| Aliases | phosphodiesterase 3B, cGMP-inhibited |
| Synonyms | 3',5'-Cyclic phosphodiesterase B, 9830102A01RIK, cAMP-Dependent 3',5'-Cyclic Phosphodiesterase, CGI PDE, cGIPDE1, Cgmp-inhibited 3',5'-cyclic phosphodiesterase b, HcGIP1, LOC124902638, PDE3, Phosphodiesterase 3b, phosphodiesterase 3B, cGMP-inhibited, RcGIPl |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pde3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metal dependent phosphohydrolases with conserved 'HD' motif
- 3'5'-cyclic nucleotide phosphodiesterase
- protein kinase binding
- 3',5'-cyclic-GMP phosphodiesterase
- cAMP-specific phosphodiesterase
- phosphoprotein binding
- enzyme
- protein binding
- HDc
- 3',5'-cyclic-nucleotide phosphodiesterase
Pathways
Biological processes and signaling networks where the Pde3b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Apelin Pancreas Signaling Pathway
- cAMP-mediated signaling
- Cardiac β-adrenergic Signaling
- Cellular Effects of Sildenafil (Viagra)
- G-Protein Coupled Receptor Signaling
- Gustation Pathway
- Insulin Receptor Signaling
- Leptin Signaling in Obesity
- Nitric Oxide Signaling in the Cardiovascular System
- RAR Activation
- Relaxin Signaling
- TR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rheumatoid arthritis
- Alzheimer disease
- obesity
- cardiovascular disorder
- metastasis
- heart disease
- hypertension
- renal failure
- chronic bronchitis
role in cell
- expression in
- lipolysis in
- proliferation
- migration
- formation
- morphology
- binding in
- adhesion
- size
- cell spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pde3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- negative regulation of cell adhesion mediated by integrin
- negative regulation of angiogenesis
- G-protein coupled receptor signaling pathway
- angiogenesis
- negative regulation of cell adhesion
- cAMP-mediated signaling
- negative regulation of lipid catabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- cytosol
- guanyl-nucleotide exchange factor complex
- Golgi apparatus
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
- protein binding
- metal ion binding
- protein kinase B binding
- 3',5'-cyclic-GMP phosphodiesterase activity
- 3',5'-cyclic-AMP phosphodiesterase activity
- 3',5'-cyclic-nucleotide phosphodiesterase activity