Rnf20 Gene Summary [Mouse]
Enables chromatin binding activity and histone H2B C-terminal K residue ubiquitin ligase activity. Predicted to be involved in several processes, including positive regulation of transcription by RNA polymerase II; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of HULC complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human RNF20 (ring finger protein 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf20 |
| Official Name | ring finger protein 20 [Source:MGI Symbol;Acc:MGI:1925927] |
| Ensembl ID | ENSMUSG00000028309 |
| Bio databases IDs | |
| Aliases | ring finger protein 20 |
| Synonyms | 4833430L21Rik, BRE1, BRE1A, hBRE1, mKIAA4116, RING FINGER protein 20 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- histone binding
- transcription co-activator
- ubiquitin protein ligase activity
- chromatin binding
- enzyme
- p53 binding
- protein binding
- identical protein binding
- RecF/RecN/SMC N terminal domain
- mRNA 3' UTR binding
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- congenital heart disease
- glioblastoma
- glioblastoma cancer
- aspermatogenesis
role in cell
- expression in
- proliferation
- activation in
- migration
- apoptosis
- formation
- formation in
- differentiation
- breakage
- olaparib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- protein polyubiquitination
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of cell migration
- regulation of mitotic cell cycle
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- nucleolus
- HULC complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- p53 binding
- ubiquitin protein ligase binding
- protein binding
- transcription coactivator activity
- metal ion binding
- histone binding
- chromatin binding
- mRNA 3'-UTR binding