Aen Gene Summary [Mouse]
Predicted to enable DNA exonuclease activity. Predicted to be involved in RNA processing; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; and response to ionizing radiation. Predicted to be located in nuclear membrane; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Is expressed in cerebral cortex and telencephalon. Orthologous to human AEN (apoptosis enhancing nuclease). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Aen |
| Official Name | apoptosis enhancing nuclease [Source:MGI Symbol;Acc:MGI:1915298] |
| Ensembl ID | ENSMUSG00000030609 |
| Bio databases IDs | |
| Aliases | apoptosis enhancing nuclease |
| Synonyms | 2700083B06Rik, apoptosis enhancing nuclease, FLJ12484, ISG20L1, pp12744, RGD1305051 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aen often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- exodeoxyribonuclease
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- exonuclease
- EXOIII
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aen gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- DNA metabolic process
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding
- exonuclease activity
- exodeoxyribonuclease activity