Lzts2 Gene Summary [Mouse]
Acts upstream of or within several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of fibroblast proliferation; and tube morphogenesis. Located in cytoplasm. Is expressed in several structures, including 1st branchial arch mandibular component; adrenal gland; forelimb bud; future brain; and genitourinary system. Used to study urinary system disease. Orthologous to human LZTS2 (leucine zipper tumor suppressor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lzts2 |
| Official Name | leucine zipper, putative tumor suppressor 2 [Source:MGI Symbol;Acc:MGI:2385095] |
| Ensembl ID | ENSMUSG00000035342 |
| Bio databases IDs | |
| Aliases | leucine zipper, putative tumor suppressor 2 |
| Synonyms | LAPSER1, leucine zipper, putative tumor suppressor 2, leucine zipper, putative tumour suppressor 2, leucine zipper tumor suppressor 2, leucine zipper tumour suppressor 2, mKIAA1813 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lzts2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crescentin protein
- Fez1
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gallbladder cancer
- biliary tract cancer
- cancer
- neoplasia
- major depression
- dilation of ureter
- hydronephrosis
- pancreatic neoplasia
- epithelial neoplasia
- hematologic cancer
role in cell
- apoptosis
- proliferation
- cell death
- growth
- formation
- colony formation
- transformation
- binucleation
- mitotic catastrophe
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic region
- Plasma Membrane
- vesicles
- centrosome
- midbody
- intercellular junctions
- cytosol
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lzts2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fibroblast proliferation
- negative regulation of canonical Wnt receptor signaling pathway
- primary ureteric bud growth
- ureter morphogenesis
- negative regulation of protein localization to nucleus
- spindle midzone assembly
- microtubule severing
- nuclear export
- negative regulation of fibroblast proliferation
- cytokinesis after mitosis
- Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- centrosome
- vesicle
- cytosol
- midbody
- plasma membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding