Sez6l2 Gene Summary [Mouse]

Acts upstream of or within activation of protein kinase C activity; adult locomotory behavior; and nervous system development. Located in endoplasmic reticulum and neuronal cell body. Is expressed in adrenal medulla; gut; nervous system; neural retina; and olfactory epithelium. Orthologous to human SEZ6L2 (seizure related 6 homolog like 2). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Sez6l2
Official Name
seizure related 6 homolog like 2 [Source:MGI Symbol;Acc:MGI:2385295]
Ensembl ID
ENSMUSG00000030683
Bio databases IDs NCBI: 233878 Ensembl: ENSMUSG00000030683
Aliases seizure related 6 homolog like 2
Synonyms AI835913, AW121566, BSRP-A, PSK-1, RGD1565281, seizure related 6 homolog like 2
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sez6l2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • CCP
  • CUB
  • Sushi repeat (SCR repeat)
  • SUSHI repeat

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • organismal death
  • COVID-19
  • systemic lupus erythematosus
regulated by
role in cell
  • maturation
  • innervation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Endoplasmic Reticulum
  • synaptic vesicles
  • perikaryon

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Sez6l2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • regulation of protein kinase C signaling cascade
  • synapse maturation

Cellular Component

Where in the cell the gene product is active
  • endoplasmic reticulum membrane
  • endoplasmic reticulum
  • neuronal cell body
  • plasma membrane

Gene-Specific Assays for Results You Can Trust

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