Il1r2 Gene Summary [Mouse]
Enables interleukin-1 binding activity and interleukin-1 receptor activity. Acts upstream of or within negative regulation of gene expression and negative regulation of interleukin-1-mediated signaling pathway. Located in cytoplasm. Is expressed in several structures, including gut; pituitary gland; reproductive system; thymus; and trachea. Human ortholog(s) of this gene implicated in aggressive periodontitis; esophageal cancer; lung cancer; and organ system cancer. Orthologous to human IL1R2 (interleukin 1 receptor type 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il1r2 |
| Official Name | interleukin 1 receptor, type II [Source:MGI Symbol;Acc:MGI:96546] |
| Ensembl ID | ENSMUSG00000026073 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor, type II |
| Synonyms | CD121b, CDW121B, IL-1 beta r, IL1bRb, IL1R2c, IL1RB, IL-1RT-2, IL-1R type II, IL-1 β r, interleukin 1 receptor type 2, interleukin 1 receptor, type II |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Il1r2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- CD19_double_Ig
- immunoglobulin domain
- stalk region
- Immunoglobulin like
- transmembrane domain
- Immunoglobulin I-set domain
- protein binding
- interleukin-1 receptor
- interleukin-1 binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Il1r2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- FAK Signaling
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- NF-κB Signaling
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- PPARα/RXRα Activation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- STAT3 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- endometriosis
- arthritis
- oral submucous fibrosis
- familial hemophagocytic lymphohistiocytosis
- insulin-dependent diabetes mellitus
- Sjogren syndrome keratoconjunctivitis sicca
- K/BxN serum transfer arthritis
- Parkinson disease
- colorectal cancer
role in cell
- cellular infiltration by
- expression in
- function
- response
- number
- abnormal number
- apoptosis
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- membrane surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Il1r2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- negative regulation of protein processing
- negative regulation of interleukin-1 alpha production
- cytokine-mediated signaling pathway
- negative regulation of cytokine production involved in inflammatory response
- protein processing
- negative regulation of interleukin-1-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- interleukin-1, Type II, blocking receptor activity
- protein binding
- interleukin-1 receptor activity
- interleukin-1 binding