Cd200r1 Gene Summary [Mouse]
Enables signaling receptor activity. Predicted to be involved in several processes, including negative regulation of interleukin-6 production; negative regulation of mononuclear cell migration; and negative regulation of neuroinflammatory response. Located in external side of plasma membrane. Is expressed in central nervous system; liver lobe; retina; and thymus primordium. Orthologous to several human genes including CD200R1 (CD200 receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd200r1 |
| Official Name | CD200 receptor 1 [Source:MGI Symbol;Acc:MGI:1889024] |
| Ensembl ID | ENSMUSG00000022667 |
| Bio databases IDs | |
| Aliases | CD200 receptor 1 |
| Synonyms | CD200R, CD200 receptor 1, Cd200rla, CRTR2, HCRTR2, MOX2R, OX2R |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd200r1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Fc receptor
- signaling receptor activity
- binding protein
- immunoglobulin domain
- cell adhesion molecule binding
- signal peptide
- protein binding
- transmembrane receptor
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Cd200r1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nocturia
- cancer
- metastasis
- liver cancer
- liver neoplasia
- digestive system cancer
- abdominal cancer
- collagen-induced arthritis
- insomnia
- liver metastasis
role in cell
- number
- phosphorylation in
- expression in
- proliferation
- quantity
- fusion
- response
- function
- degranulation
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd200r1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-6 production
- negative regulation of T cell migration
- signal transduction
- heterotypic cell-cell adhesion
- intracellular signal transduction
- Fc receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- immunoglobulin receptor activity