Sgf29 Gene Summary [Mouse]
Enables methylation-dependent protein binding activity. Involved in several processes, including regulation of DNA repair; regulation of cell division; and regulation of embryonic development. Acts upstream of or within DNA repair and negative regulation of DNA repair. Part of ATAC complex. Is expressed in genital tubercle; limb; and limb mesenchyme. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human SGF29 (SAGA complex associated factor 29). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Sgf29 |
| Official Name | SAGA complex associated factor 29 [Source:MGI Symbol;Acc:MGI:1922815] |
| Ensembl ID | ENSMUSG00000030714 |
| Bio databases IDs | |
| Aliases | SAGA complex associated factor 29 |
| Synonyms | 1700023O11RIK, 9530025I05Rik, CCDC101, RGD1310609, SAGA complex associated factor 29, STAF36, TDRD29 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sgf29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- SGF29 tudor-like domain
- protein binding activity, bridging
- protein binding
- Tudor domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- refractive error
- pervasive developmental disorder
- inflammatory bowel disease
- eczema
- chronic obstructive pulmonary disease
- allergy
role in cell
- quantity
- cell cycle progression
- activation in
- acetylation in
- trimethylation in
- association in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sgf29 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of gene expression, epigenetic
- regulation of DNA repair
- regulation of tubulin deacetylation
- regulation of embryonic development
- regulation of transcription, DNA-dependent
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell division
- positive regulation of transcription, DNA-dependent
- regulation of RNA splicing
- establishment of protein localization to chromatin
- regulation of cell cycle
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- mitotic spindle
- SAGA-type complex
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- methylated histone residue binding