Edc4 Gene Summary [Mouse]

The protein encoded by this gene is thought to promote mRNA decay, and is known to interact with several mRNA decapping proteins. In humans, decreased expression of this gene prevents the accumulation of mRNA decapping proteins to mRNA processing bodies (P-body). Alternative splicing results in multiple protein isoforms. [provided by RefSeq, Jul 2014]

Details

Type
Protein Coding
Official Symbol
Edc4
Official Name
enhancer of mRNA decapping 4 [Source:MGI Symbol;Acc:MGI:2446249]
Ensembl ID
ENSMUSG00000036270
Bio databases IDs NCBI: 234699 Ensembl: ENSMUSG00000036270
Aliases enhancer of mRNA decapping 4
Synonyms BC022641, enhancer of mRNA decapping 4, GE1, HEDL5, HEDLS, LRRG00115, Nrn1l, RCD-8, RGD1309136
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Edc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • WD40 repeats
  • WD40 region of Ge1, enhancer of mRNA-decapping protein
  • WD domain, G-beta repeat
  • protein binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • metabolic syndrome X
  • Burkitt lymphoma
  • B-cell non-Hodgkin disease
  • mature B-cell neoplasia
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • GW body
  • cytoplasmic ribonucleoprotein granule
  • cytoplasmic mRNA processing body
  • Nucleus
  • cytoplasmic aggregates
  • cytosol
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Edc4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • deadenylation-independent decapping of nuclear-transcribed mRNA

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasm
  • membrane
  • cytoplasmic mRNA processing body
  • cytosol
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

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