Rab11fip5 Gene Summary [Mouse]
Predicted to enable gamma-tubulin binding activity. Involved in insulin secretion involved in cellular response to glucose stimulus; postsynaptic neurotransmitter receptor internalization; and regulated exocytosis. Acts upstream of or within cellular response to type II interferon. Located in Golgi apparatus and cytoplasmic vesicle. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human RAB11FIP5 (RAB11 family interacting protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab11fip5 |
| Official Name | RAB11 family interacting protein 5 (class I) [Source:MGI Symbol;Acc:MGI:1098586] |
| Ensembl ID | ENSMUSG00000051343 |
| Bio databases IDs | |
| Aliases | RAB11 family interacting protein 5 (class I) |
| Synonyms | 9130206P09Rik, D6Ertd32e, GAF1, pp75, RAB11 family interacting protein 5, RAB11 family interacting protein 5 (class I), RIP11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab11fip5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- gamma-tubulin binding
- Rab11 binding domain
- FIP domain
- protein binding
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- epithelial uterine cancer
- cervical cancer
- cervical small cell carcinoma
- extrapulmonary small cell cancer
regulates
- ADIPOQ
- RAB11
role in cell
- long term synaptic depression
- response by
- entrance
- synaptic transmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cilia
- Plasma Membrane
- basal bodies
- endosomes
- centrosome
- Golgi Apparatus
- Mitochondria
- mitochondrial outer membrane
- endosomal membrane
- nuclear speckles
- recycling endosomes
- early endosomes
- secretory granules
- presynaptic terminals
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab11fip5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein localization at cell surface
- insulin secretion involved in cellular response to glucose stimulus
- negative regulation of adiponectin secretion
- regulated secretory pathway
- cellular response to acidity
Cellular Component
Where in the cell the gene product is active
- secretory granule
- centriolar satellite
- phagocytic vesicle
- Golgi membrane
- Golgi apparatus
- mitochondrial outer membrane
- early endosome membrane
- early endosome
- transport vesicle membrane
- intracellular membrane-bounded organelle
- mitochondrion
- recycling endosome
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- gamma-tubulin binding