Nckap1 Gene Summary [Mouse]
Predicted to contribute to small GTPase binding activity. Involved in positive regulation of actin filament polymerization and positive regulation of lamellipodium assembly. Acts upstream of or within several processes, including apical protein localization; embryonic morphogenesis; and segmentation. Located in lamellipodium and ruffle. Part of filamentous actin. Is active in postsynapse. Is expressed in several structures, including alimentary system; genitourinary system; immune system; nervous system; and sensory organ. Orthologous to human NCKAP1 (NCK associated protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nckap1 |
| Official Name | NCK-associated protein 1 [Source:MGI Symbol;Acc:MGI:1355333] |
| Ensembl ID | ENSMUSG00000027002 |
| Bio databases IDs | |
| Aliases | NCK-associated protein 1 |
| Synonyms | H19, HEM2, mh19, mKIAA0587, NAP1, NAP125, NCK-associated protein 1, p125Nap1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nckap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nck-associated protein 1
- Nap1-binding site
- cytoplasmic domain
- enzyme binding
- protein binding
Pathways
Biological processes and signaling networks where the Nckap1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- prostate cancer
- lung squamous cell carcinoma
- gastric cancer
- squamous cell lung cancer
- metastasis
- COVID-19
- breast cancer
- bladder cancer
- endometrioid cancer
role in cell
- apoptosis
- migration
- invasion by
- binding in
- differentiation
- polymerization
- invasiveness
- assembly
- polarization
- nucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- ruffle
- Cytoplasm
- postsynaptic region
- cellular membrane
- actin filaments
- cytosol
- growth cone
- synaptosomes
- cell membrane leading edge
- axons
- dendrites
- postsynaptic density
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nckap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of lamellipodium assembly
- Rac protein signal transduction
- cortical actin cytoskeleton organization
- central nervous system development
- cell projection assembly
- cell morphogenesis
- positive regulation of actin filament polymerization
- apoptotic process
- neuron projection morphogenesis
- positive regulation of Arp2/3 complex-mediated actin nucleation
- cell migration
Cellular Component
Where in the cell the gene product is active
- SCAR complex
- extracellular vesicular exosome
- focal adhesion
- ruffle
- cytosol
- filamentous actin
- lamellipodium
- lamellipodium membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding