Chrdl2 Gene Summary [Mouse]
Predicted to enable BMP binding activity. Acts upstream of or within chondrocyte differentiation and negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Is expressed in colon; genitourinary system; liver; and musculoskeletal system. Orthologous to human CHRDL2 (chordin like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Chrdl2 |
| Official Name | chordin-like 2 [Source:MGI Symbol;Acc:MGI:1916371] |
| Ensembl ID | ENSMUSG00000030732 |
| Bio databases IDs | |
| Aliases | chordin-like 2 |
| Synonyms | 1810022C01RIK, BNF1, CHL2, chordin-like 2, LOC100360934 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chrdl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- von Willebrand factor type C domain
- Chordin-like protein 1/2 C-terminal
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- uterine leiomyoma
- leiomyomatosis
- diabetic nephropathy
- colorectal adenoma
- colorectal adenoma formation
- dextran sodium sulfate-induced colitis
role in cell
- expression in
- differentiation
- mineralization
- deposition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chrdl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- ossification
- cell differentiation
- cartilage development
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- BMP binding