Pou4f2 Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; p53 binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to estradiol stimulus; regulation of DNA-templated transcription; and regulation of neuron projection development. Acts upstream of or within several processes, including axonogenesis; neuromuscular process controlling balance; and sensory perception of sound. Located in cytoplasm; euchromatin; and nucleus. Is expressed in several structures, including central nervous system; glomerular tuft; placenta; somite; and visual system. Orthologous to human POU4F2 (POU class 4 homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pou4f2 |
| Official Name | POU domain, class 4, transcription factor 2 [Source:MGI Symbol;Acc:MGI:102524] |
| Ensembl ID | ENSMUSG00000031688 |
| Bio databases IDs | |
| Aliases | POU domain, class 4, transcription factor 2 |
| Synonyms | BRN3.2, BRN3B, mBrn3-3R, OCT-T2, POU4F-RS1, POU class 4 homeobox 2, POU domain, class 4, transcription factor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pou4f2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- chromatin binding
- p53 binding
- protein binding
- sequence-specific DNA binding
- Pou domain - N-terminal to homeobox domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- POU specific domain
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Ewing sarcoma
- hypoplasia
- osteosarcomagenesis
- abnormal visual pursuit
role in cell
- expression in
- apoptosis
- survival
- growth
- proliferation
- colony formation
- differentiation
- outgrowth
- function
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pou4f2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of retinal ganglion cell axon guidance
- retina development in camera-type eye
- positive regulation of programmed cell death
- axon guidance
- positive regulation of transcription from RNA polymerase II promoter
- regulation of sequence-specific DNA binding transcription factor activity
- cellular response to insulin stimulus
- sensory perception of sound
- negative regulation of transcription from RNA polymerase II promoter
- MAPK cascade
- heart development
- cellular response to estradiol stimulus
- positive regulation of transcription regulatory region DNA binding
- positive regulation of osteoclast differentiation
- negative regulation of cell differentiation
- intracellular estrogen receptor signaling pathway
- retinal ganglion cell axon guidance
- neuron differentiation
- positive regulation of glucose import
- positive regulation of axon extension
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of cell differentiation
- regulation of transcription from RNA polymerase II promoter
- axon extension
- signal transduction by p53 class mediator resulting in induction of apoptosis
- cellular response to cytokine stimulus
- neuromuscular process controlling balance
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- euchromatin
- cytoplasm
- nuclear speck
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity