Acsm3 Gene Summary [Mouse]
Enables medium-chain fatty acid-CoA ligase activity and propionate CoA-transferase activity. Acts upstream of or within fatty acid biosynthetic process. Located in mitochondrial matrix. Is expressed in alimentary system; integumental system; and lower urinary tract. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human ACSM3 (acyl-CoA synthetase medium chain family member 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acsm3 |
| Official Name | acyl-CoA synthetase medium-chain family member 3 [Source:MGI Symbol;Acc:MGI:99538] |
| Ensembl ID | ENSMUSG00000030935 |
| Bio databases IDs | |
| Aliases | acyl-CoA synthetase medium-chain family member 3 |
| Synonyms | acyl-CoA synthetase medium-chain family member 3, LOC105379461, SA, SAH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acsm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- fatty-acid ligase
- benzoate-CoA ligase family
- AMP-binding enzyme
- acetate--CoA ligase
- propionate CoA-transferase
- CoA-ligase
- Adenylate forming domain, Class I superfamily
- enzyme
- protein binding
- AMP-binding enzyme C-terminal domain
- amino acid adenylation domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- diabetic nephropathy
- epithelial cancer
- schizophrenia
- diabetes mellitus
- hepatocellular carcinoma
- insomnia
- Hodgkin lymphoma
- Hodgkin disease
- peripheral arterial disease
regulates
- fatty acid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acsm3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- fatty acid biosynthetic process
- regulation of blood pressure
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- medium-chain fatty acid-CoA ligase activity
- ATP binding
- branched-chain acyl-CoA synthetase (ADP-forming) activity
- propionate CoA-transferase activity
- metal ion binding
- propionate-CoA ligase activity
- fatty-acyl-CoA synthase activity
- fatty acid ligase activity