Lrp4 Gene Summary [Mouse]
Enables coreceptor activity; protein homodimerization activity; and receptor tyrosine kinase binding activity. Involved in several processes, including positive regulation of Rac protein signal transduction; regulation of synapse organization; and synapse organization. Acts upstream of or within several processes, including Rac protein signal transduction; negative regulation of canonical Wnt signaling pathway; and regionalization. Located in neuromuscular junction and plasma membrane. Is active in synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and limb bud. Used to study sclerosteosis 2. Human ortholog(s) of this gene implicated in Cenani-Lenz syndactyly syndrome; congenital myasthenic syndrome 17; and sclerosteosis 2. Orthologous to human LRP4 (LDL receptor related protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrp4 |
| Official Name | low density lipoprotein receptor-related protein 4 [Source:MGI Symbol;Acc:MGI:2442252] |
| Ensembl ID | ENSMUSG00000027253 |
| Bio databases IDs | |
| Aliases | low density lipoprotein receptor-related protein 4 |
| Synonyms | 6430526J12RIK, CLSS, CMS17, D230026E03, LDL receptor related protein 4, low density lipoprotein receptor-related protein 4, LRP10, mdig, MEGF7, SOST2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Complement Clr-like EGF-like
- ectodomain
- Low-density lipoprotein receptor repeat class B
- protein binding
- NHL repeat unit of beta-propeller proteins
- EGF_CA
- receptor tyrosine kinase binding
- ligand-binding domain
- transmembrane domain
- extracellular beta-propeller structured domain
- LDLa
- protein homodimerization
- cytosolic tail domain
- Low-density lipoprotein-receptor YWTD domain
- Coagulation Factor Xa inhibitory site
- coreceptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- migraines
- hypoplasia
- Huntington disease
- venous thromboembolism
- congenital myasthenic syndrome type 17
- Alzheimer disease
- schizophrenia
- major depression
- sclerosteosis type 2
- depressive disorder
phenotypes
- abnormal apical ectodermal ridge morphology
- abnormal autopod morphology
- abnormal blood homeostasis
- abnormal chondrocyte morphology
- abnormal coat appearance
- abnormal digit morphology
- abnormal enamel morphology
- abnormal forelimb morphology
- abnormal hair follicle development
- abnormal hindlimb morphology
- abnormal incisor morphology
- abnormal kidney development
- abnormal mammary gland bud morphology
- abnormal molar cusp morphology
- abnormal motor neuron morphology
- abnormal neuromuscular synapse morphology
- abnormal nursing
- abnormal osteocyte morphology
- abnormal phrenic nerve morphology
- abnormal postnatal growth
- abnormal spine curvature
- abnormal tail morphology
- abnormal tooth development
- abnormal tooth morphology
- abnormal ureteric bud invasion
- abnormal ureteric bud morphology
- abnormal vibrissa morphology
- absent kidney
- absent metanephric mesenchyme
- atelectasis
- brachydactyly
- cyanosis
- decreased body size
- decreased bone trabecular spacing
- deformed nails
- ectopic digits
- failure of neuromuscular synapse postsynaptic differentiation
- failure of neuromuscular synapse presynaptic differentiation
- fused metacarpal bones
- fused metatarsal bones
- fused phalanges
- hunched posture
- impaired branching involved in ureteric bud morphogenesis
- increased bone ossification
- increased bone strength
- increased bone trabecula number
- increased diameter of femur
- increased femur compact bone thickness
- increased trabecular bone connectivity density
- increased trabecular bone thickness
- increased trabecular bone volume
- neonatal lethality complete penetrance
- no spontaneous movement
- oligodactyly
- perinatal lethality complete penetrance
- polydactyly
- polysyndactyly
- preweaning lethality incomplete penetrance
- reduced fertility
- respiratory failure
- single kidney
- small lung
- supernumerary incisors
- syndactyly
- thick apical ectodermal ridge
- thick neurocranium
- ureter hypoplasia
role in cell
- formation
- formation in
- expression in
- abnormal morphology
- number
- loss in
- phosphorylation in
- quantity
- differentiation
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cellular membrane
- Plasma Membrane
- synaptic membrane
- neuromuscular junctions
- synapse
- membrane rafts
- perikaryon
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rac protein signal transduction
- synapse organization
- limb development
- odontogenesis of dentin-containing tooth
- enzyme linked receptor protein signaling pathway
- generation of neurons
- endocytosis
- proximal/distal pattern formation
- dorsal/ventral pattern formation
- embryonic digit morphogenesis
- dendrite morphogenesis
- negative regulation of canonical Wnt receptor signaling pathway
- skeletal muscle acetylcholine-gated channel clustering
- negative regulation of axonogenesis
- synaptic growth at neuromuscular junction
- hair follicle development
- postsynaptic membrane assembly
- kidney development
- presynaptic membrane assembly
- Wnt receptor signaling pathway
- negative regulation of ossification
- positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- dendrite
- neuromuscular junction
- neuronal cell body
- synaptic membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- apolipoprotein binding
- coreceptor activity
- scaffold protein binding
- protein homodimerization activity
- protein binding
- calcium ion binding
- receptor tyrosine kinase binding