Eef1akmt2 Gene Summary [Mouse]

Predicted to enable protein-lysine N-methyltransferase activity. Predicted to be involved in peptidyl-lysine methylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human EEF1AKMT2 (EEF1A lysine methyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Eef1akmt2
Official Name
EEF1A lysine methyltransferase 2 [Source:MGI Symbol;Acc:MGI:1919346]
Ensembl ID
ENSMUSG00000030960
Bio databases IDs NCBI: 72096 Ensembl: ENSMUSG00000030960
Aliases EEF1A lysine methyltransferase 2
Synonyms 2010208K18Rik, C10orf138, EEF1A lysine methyltransferase 2, Efm4, FLJ12292, METTL10, RGD1306300
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eef1akmt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein-lysine N-methyltransferase
  • methyltransferase
  • enzyme
  • AdoMet_MTases
  • methyltransferase domain

Pathways

Biological processes and signaling networks where the Eef1akmt2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • ulcerative colitis
  • inflammatory bowel disease
  • Crohn disease
  • gout
regulated by
  • dexamethasone
  • PRDM2
  • troglitazone
  • rifampin
  • ritonavir

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Nucleus
  • cytosol
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Eef1akmt2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • chromatin remodeling
  • peptidyl-lysine methylation

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasm
  • cytosol
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • histone methyltransferase activity
  • methyltransferase activity
  • protein-lysine N-methyltransferase activity

Gene-Specific Assays for Results You Can Trust

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