Pak3

Enables protein kinase activity and small GTPase binding activity. Involved in axonogenesis; dendritic spine morphogenesis; and regulation of postsynapse organization. Acts upstream of or within dendritic spine development. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including central nervous system; gonad; liver; retina; and sciatic nerve. Used to study non-syndromic X-linked intellectual disability 30. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pak3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Pak3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Pak3 gene, providing context for its role in the cell.