Vbp1 Gene Summary [Mouse]
Predicted to enable amyloid-beta binding activity; tubulin binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including negative regulation of amyloid fibril formation; protein folding; and tubulin complex assembly. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Orthologous to human VBP1 (VHL binding protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vbp1 |
| Official Name | von Hippel-Lindau binding protein 1 [Source:MGI Symbol;Acc:MGI:1333804] |
| Ensembl ID | ENSMUSG00000031197 |
| Bio databases IDs | |
| Aliases | von Hippel-Lindau binding protein 1 |
| Synonyms | HIBBJ46, IMIDOPEPTIDASE, PFD3, PFDN3, VHL binding protein 1, von Hippel-Lindau binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prefoldin subunit
- prefoldin
- protein binding
- beta-amyloid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
role in cell
- expression in
- growth
- cell viability
- degradation in
- K48 polyubiquitination in
- K63 polyubiquitination in
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- cytoplasmic aggregates
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tubulin complex assembly
- chaperone-mediated protein folding
- protein folding
- microtubule-based process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- prefoldin complex
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein binding
- unfolded protein binding
- beta-amyloid binding