Myom2 Gene Summary [Mouse]
Predicted to enable kinase binding activity. Predicted to be involved in sarcomere organization. Predicted to act upstream of or within muscle contraction. Located in M band. Is expressed in several structures, including heart; limb; notochord; paraxial mesenchyme; and skeletal musculature. Orthologous to human MYOM2 (myomesin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myom2 |
| Official Name | myomesin 2 [Source:MGI Symbol;Acc:MGI:1328358] |
| Ensembl ID | ENSMUSG00000031461 |
| Bio databases IDs | |
| Aliases | myomesin 2 |
| Synonyms | M-protein, myomesin 2, TTNAP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myom2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of muscle
- kinase binding
- structural constituent of cytoskeleton
- FN3
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- Huntington disease
- diabetic peripheral neuropathy
- migraines
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- early missed abortion
role in cell
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- myofilaments
- sarcomere
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myom2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle contraction
- sarcomere organization
- extraocular skeletal muscle development
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- myosin filament
- M band
Molecular Function
What the gene product does at the molecular level
- structural constituent of muscle
- protein binding
- kinase binding