Jmjd1c Gene Summary [Mouse]
Predicted to enable chromatin DNA binding activity; histone H3K9 demethylase activity; and transcription coregulator activity. Acts upstream of or within epithelial cell morphogenesis; male germ-line stem cell population maintenance; and seminiferous tubule development. Predicted to be located in nucleus. Predicted to be part of histone deacetylase complex. Predicted to be active in chromatin. Is expressed in several structures, including central nervous system; genitourinary system; heart; inner ear; and limb. Orthologous to human JMJD1C (jumonji domain containing 1C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Jmjd1c |
| Official Name | jumonji domain containing 1C [Source:MGI Symbol;Acc:MGI:1918614] |
| Ensembl ID | ENSMUSG00000037876 |
| Bio databases IDs | |
| Aliases | jumonji domain containing 1C |
| Synonyms | 5430433L24RIK, AC156272.1, D630035I23Rik, Jmjdic, jumonji domain containing 1C, KDM3C, Pr2, TRIP-8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Jmjd1c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- enzyme
- protein binding
- thyroid hormone receptor binding
- histone demethylase activity
- RmlC-like cupin superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombocytopenia
- gallstone
- neoplasia
- Alzheimer disease
- ischemic stroke
- gout
- venous thromboembolism
- mammary neoplasm
- non-insulin-dependent diabetes mellitus
- insomnia
role in cell
- growth
- expression in
- binding in
- proliferation
- apoptosis
- differentiation
- number
- survival
- signaling in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Jmjd1c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- regulation of transcription, DNA-dependent
- blood coagulation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- histone deacetylase complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- dioxygenase activity
- chromatin DNA binding
- protein binding
- transcription cofactor activity
- metal ion binding
- histone demethylase activity (H3-K9 specific)
- thyroid hormone receptor binding