Smtnl1 Gene Summary [Mouse]
Enables several functions, including calmodulin binding activity; protein domain specific binding activity; and protein phosphatase 1 binding activity. Involved in negative regulation of DNA-templated transcription and positive regulation of vasoconstriction. Acts upstream of or within several processes, including peptidyl-serine phosphorylation; response to activity; and vasoconstriction. Located in I band; M band; and nucleus. Is expressed in several structures, including aorta; diaphragm; genitourinary system; intestine; and skeletal muscle. Orthologous to human SMTNL1 (smoothelin like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smtnl1 |
| Official Name | smoothelin-like 1 [Source:MGI Symbol;Acc:MGI:1915928] |
| Ensembl ID | ENSMUSG00000027077 |
| Bio databases IDs | |
| Aliases | smoothelin-like 1 |
| Synonyms | 1110030K22RIK, CHASM, RGD1311701, smoothelin-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Smtnl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase inhibitor activity
- protein phosphatase 1 binding
- Calponin homology domain
- myosin phosphatase regulator
- calmodulin binding
- tropomyosin binding
- calponin homology (CH) domain superfamily
- protein domain specific binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fatigue
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- sarcomere
- cytosol
- myofibrils
- I band
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Smtnl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- positive regulation of vasoconstriction
- vasoconstriction
- muscle organ morphogenesis
- response to activity
- response to xenobiotic stimulus
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- contractile fiber
- microtubule organizing center
- cytoplasm
- I band
- M band
- filamentous actin
Molecular Function
What the gene product does at the molecular level
- CH domain binding
- calmodulin binding
- protein phosphatase 1 binding
- tropomyosin binding