Twf1 Gene Summary [Mouse]
Enables actin monomer binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein tyrosine kinase activity. Involved in barbed-end actin filament capping and positive regulation of cardiac muscle hypertrophy. Located in several cellular components, including filopodium; myofibril; and perinuclear region of cytoplasm. Colocalizes with ruffle membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TWF1 (twinfilin actin binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Twf1 |
| Official Name | twinfilin actin binding protein 1 [Source:MGI Symbol;Acc:MGI:1100520] |
| Ensembl ID | ENSMUSG00000022451 |
| Bio databases IDs | |
| Aliases | twinfilin actin binding protein 1 |
| Synonyms | A6, PRTK, PTK9, TWINFILIN, twinfilin actin-binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Twf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Cofilin/tropomyosin-type actin-binding protein
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- binding protein
- actin monomer binding
- phosphatidylinositol-4,5-bisphosphate binding
- actin binding
- ATP binding
- linker domain
- protein binding
- actin depolymerizing factor homology domain
- protein-tyrosine kinase
Pathways
Biological processes and signaling networks where the Twf1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- psoriasis
- lymphomagenesis
- lung adenocarcinoma
- lung adenocarcinoma formation
- uterine leiomyoma
- leiomyomatosis
- organismal death
- hematologic cancer
role in cell
- expression in
- phosphorylation in
- number
- polymerization
- migration
- actin capping
- invasion by
- assembly
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- actin cytoskeleton
- intercellular junctions
- cytosol
- membrane ruffles
- myofibrils
- filopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Twf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin phosphorylation
- regulation of lamellipodium assembly
- barbed-end actin filament capping
- sequestering of actin monomers
- negative regulation of actin filament polymerization
- actin filament depolymerization
- positive regulation of cardiac muscle hypertrophy
- positive regulation of neuron projection development
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- actin cytoskeleton
- filopodium
- cytosol
- ruffle membrane
- actin filament
- myofibril
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein tyrosine kinase activity
- protein binding
- actin binding
- cadherin binding
- actin monomer binding