Tln1 Gene Summary [Mouse]
Enables integrin binding activity; phosphatidylinositol binding activity; and phosphatidylserine binding activity. Involved in cortical microtubule organization; integrin activation; and integrin-mediated signaling pathway. Acts upstream of or within cell-substrate junction assembly and cortical actin cytoskeleton organization. Located in focal adhesion. Is expressed in several structures, including body cavity or lining; cardiovascular system; nervous system; submandibular gland; and vertebral axis musculature. Orthologous to human TLN1 (talin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tln1 |
| Official Name | talin 1 [Source:MGI Symbol;Acc:MGI:1099832] |
| Ensembl ID | ENSMUSG00000028465 |
| Bio databases IDs | |
| Aliases | talin 1 |
| Synonyms | ILWEQ, TALIN, talin-1, TLN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tln1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Talin, middle domain
- vinculin binding
- head domain
- FERM subdomain f3
- FERM subdomain f2
- FERM domain
- F0 head domain
- vinculin-binding site
- Vinculin Binding Site
- rod domain
- FERM domain B-lobe
- N-terminal or F0 domain of Talin-head FERM
- LIM-domain binding
- FERM central domain
- Band 4.1 homologues
- phospholipid binding
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- phosphatidylinositol binding
- integrin binding domain
- talin PIPKIgamma binding domain
- binding protein
- I/LWEQ domain
- Ubl1_cv_Nsp3_N-like
- integrin binding
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Tln1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- neoplasia
- chronic sinusitis
- organismal death
- acute myeloid leukemia
- metastasis
- fibrosis
- preeclampsia
- reperfusion injury
- dilated cardiomyopathy
role in cell
- expression in
- number
- phosphorylation in
- quantity
- morphology
- differentiation
- activation
- proliferation
- activation in
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- detergent resistant lipid raft fraction
- ruffle
- Cytoplasm
- cell-matrix contacts
- Extracellular Space
- cellular membrane
- focal complexes
- focal adhesions
- podosomes
- Nucleus
- costameres
- cytosol
- basolateral cell surfaces
- nuclear scaffolds
- actin stress fibers
- membrane rafts
- cell-cell adherens junctions
- cell-matrix adherens junctions
- plasma
- basement membrane
- force transduction layer
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tln1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cortical actin cytoskeleton organization
- integrin-mediated signaling pathway
- regulation of focal adhesion assembly
- cell-cell junction assembly
- cell-substrate junction assembly
- platelet aggregation
- integrin activation
Cellular Component
Where in the cell the gene product is active
- adherens junction
- extracellular vesicular exosome
- cytoskeleton
- focal adhesion
- ruffle
- cytosol
- ruffle membrane
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- phosphatidylserine binding
- protein binding
- cadherin binding
- phosphatidylinositol binding
- LIM domain binding
- vinculin binding
- integrin binding
- structural constituent of cytoskeleton