Setd6 Gene Summary [Mouse]
Predicted to enable NF-kappaB binding activity; S-adenosyl-L-methionine binding activity; and protein-lysine N-methyltransferase activity. Involved in stem cell differentiation and stem cell population maintenance. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and neural retina. Orthologous to human SETD6 (SET domain containing 6, protein lysine methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Setd6 |
| Official Name | SET domain containing 6 [Source:MGI Symbol;Acc:MGI:1913333] |
| Ensembl ID | ENSMUSG00000031671 |
| Bio databases IDs | |
| Aliases | SET domain containing 6 |
| Synonyms | 0610039J04Rik, 3110004G14Rik, FLJ21148, RGD1560538, SET domain containing 6, SET domain containing 6, protein lysine methyltransferase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Setd6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-lysine N-methyltransferase
- binding protein
- SET domain
- NF-kappaB binding
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- enzyme
- protein binding
- Rubisco LSMT substrate-binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- small cell lung cancer
- organismal death
role in cell
- proliferation
- differentiation
- apoptosis
- mitosis
- phosphorylation in
- migration
- G1 phase
- metaphase
- colony formation ability
- cytokinesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Setd6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- stem cell maintenance
- stem cell differentiation
- negative regulation of NF-kappaB transcription factor activity
- regulation of inflammatory response
- peptidyl-lysine monomethylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- protein binding
- protein-lysine N-methyltransferase activity