Plk1 Gene Summary [Mouse]
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and may play a role in DNA replication during S phase. This gene is expressed in all embryonic tissues, but restricted to thymus and ovaries in adult tissues. Homozygous knockout mice were embryonic lethal, suggesting that this gene is important for early embryonic development. This gene is thought to be a potential oncogene because it is overexpressed in a variety of tumors and tumor cell lines. Depletion of this protein in cancer cells has been shown to inhibit cell proliferation and suppress oncogenic transformation; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Plk1 |
| Official Name | polo like kinase 1 [Source:MGI Symbol;Acc:MGI:97621] |
| Ensembl ID | ENSMUSG00000030867 |
| Bio databases IDs | |
| Aliases | polo like kinase 1 |
| Synonyms | PLK, polo-like kinase 1, STPK13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plk1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- protein kinase
- Kinase regulatory loop binding domain
- ATP-binding domain
- ATP binding
- Protein kinase domain
- identical protein binding
- alcohol group acceptor phosphotransferase
- Polo binding domain
- Tyrosine kinase, catalytic domain
- POLO box duplicated region
- Protein kinase (unclassified specificity)
- protein kinase binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- nuclear localization sequence
- protein binding
- magnesium ion binding
- POLO_box
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- microtubule binding
- binding protein
- Protein Kinases, catalytic domain
Pathways
Biological processes and signaling networks where the Plk1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial neoplasia
- obesity
- bladder carcinoma
- bladder cancer
- urinary tract cancer
- pelvic cancer
- bladder neoplasia
- epithelial cancer
- urological cancer
role in cell
- number
- expression in
- production in
- growth
- survival
- replication in
- apoptosis
- synthesis in
- differentiation
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- ciliary transition zone
- spindle apparatus
- Cytoplasm
- centrosome
- centriole
- Mitochondria
- midbody
- Flemming body
- metaphase plate
- cytosol
- nucleoplasm
- spindle pole
- spindle fibers
- polar microtubule
- central spindle
- mitotic spindle
- kinetochores
- centromeres
- synaptonemal complexes
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plk1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- mitotic cell cycle G2/M transition DNA damage checkpoint
- regulation of mitotic metaphase/anaphase transition
- centrosome cycle
- mitotic chromosome condensation
- mitotic nuclear envelope disassembly
- negative regulation of double-strand break repair via homologous recombination
- mitotic spindle organization
- positive regulation of proteolysis
- protein phosphorylation
- mitotic cell cycle
- double-strand break repair
- negative regulation of transcription from RNA polymerase II promoter
- G2/M transition of mitotic cell cycle
- positive regulation of ubiquitin-protein ligase activity
- regulation of protein binding
- cytokinesis after mitosis
- regulation of cytokinesis
- regulation of cell cycle
- mitotic metaphase/anaphase transition
- positive regulation of protein localization to nucleus
- sister chromatid cohesion
- nuclear envelope disassembly
- negative regulation of cyclin-dependent protein kinase activity
- regulation of mitotic cell cycle
- establishment of protein localization
- protein destabilization
- establishment of mitotic spindle orientation
- synaptonemal complex disassembly
- microtubule bundle formation
- Golgi inheritance
- protein localization to chromatin
- negative regulation of apoptotic process
- homologous chromosome segregation
- mitotic sister chromatid segregation
- positive regulation of peptidyl-threonine phosphorylation
- female meiosis chromosome segregation
- peptidyl-serine phosphorylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- centriolar satellite
- spindle pole
- kinetochore
- condensed chromosome outer kinetochore
- chromatin
- synaptonemal complex
- nucleoplasm
- nucleus
- spindle microtubule
- spindle midzone
- centrosome
- cytoplasm
- centriole
- spindle
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein kinase binding
- identical protein binding
- protein binding
- protein kinase activity
- anaphase-promoting complex binding
- protein serine/threonine kinase activity
- microtubule binding