Arl3 Gene Summary [Mouse]
Enables GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including Golgi to plasma membrane transport; photoreceptor cell development; and protein localization to ciliary membrane. Acts upstream of or within intraciliary transport and smoothened signaling pathway. Located in axoneme; ciliary basal body; and ciliary transition zone. Is expressed in central nervous system; retina nuclear layer; and skin. Used to study autosomal recessive polycystic kidney disease and retinitis pigmentosa 2. Human ortholog(s) of this gene implicated in Joubert syndrome and retinitis pigmentosa 83. Orthologous to human ARL3 (ARF like GTPase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arl3 |
| Official Name | ADP-ribosylation factor-like 3 [Source:MGI Symbol;Acc:MGI:1929699] |
| Ensembl ID | ENSMUSG00000025035 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor-like 3 |
| Synonyms | ADP-ribosylation factor-like 3, ARFL3, ARF like GTPase 3, JBTS35, LOC108353318, RP83 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ras family
- GTPase
- enzyme
- protein binding
- magnesium ion binding
- GTP binding
- Sar1p-like members of the Ras-family of small GTPases
- microtubule binding
- ADP-ribosylation factor family
- Signal recognition particle receptor beta subunit
- GTPase domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Joubert syndrome type 35
- retinitis pigmentosa
- Huntington disease
- schizophrenia
- retinitis pigmentosa type 83
role in cell
- expression in
- binding in
- growth
- senescence
- dispersal
- development
- ciliogenesis in
- assembly
- transport in
- biogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ciliary transition zone
- cilia
- Nucleus
- basal bodies
- centrosome
- Golgi Apparatus
- axonemes
- midbody
- connecting cilia
- nucleoplasm
- spindle fibers
- cytoplasmic microtubule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arl3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intraflagellar transport
- cilium morphogenesis
- small GTPase mediated signal transduction
- kidney development
- cytokinesis after mitosis
- protein transport
- photoreceptor cell development
- Golgi to plasma membrane transport
- smoothened signaling pathway
- post-Golgi vesicle-mediated transport
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- microtubule cytoskeleton
- Golgi apparatus
- Golgi membrane
- cytoplasmic microtubule
- nucleoplasm
- spindle microtubule
- nucleus
- centrosome
- extracellular vesicular exosome
- cytoplasm
- cilium
- midbody
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- GTP binding
- protein binding
- GTPase activity
- GDP binding
- microtubule binding