Arl2 Gene Summary [Mouse]
Enables GDP binding activity and GTP binding activity. Predicted to be involved in several processes, including bicellular tight junction assembly; negative regulation of GTPase activity; and regulation of generation of precursor metabolites and energy. Located in cytoplasm. Orthologous to human ARL2 (ARF like GTPase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Arl2 |
| Official Name | ADP-ribosylation factor-like 2 [Source:MGI Symbol;Acc:MGI:1928393] |
| Ensembl ID | ENSMUSG00000024944 |
| Bio databases IDs | |
| Aliases | ADP-ribosylation factor-like 2 |
| Synonyms | 2610009M23Rik, ADP-ribosylation factor-like 2, ARFL2, ARF like GTPase 2, MRCS1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- Sar1p-like members of the Ras-family of small GTPases
- ADP-ribosylation factor family
- Signal recognition particle receptor beta subunit
- GDP binding
- 50S ribosome-binding GTPase
- GTPase
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- ADP-ribosylation factor
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- neoplasia
- epithelial cancer
- liver cancer
- microcornea, rod-cone dystrophy, cataract, and posterior staphyloma type 1
role in cell
- proliferation
- function in
- growth
- glycolysis in
- fragmentation
- fragmentation in
- disruption
- cycling
- cohesion
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- focal adhesions
- Nucleus
- basal bodies
- centrosome
- Golgi Apparatus
- Mitochondria
- cytosol
- lateral plasma membrane
- mitochondrial matrix
- mitochondrial intermembrane space
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of GTPase activity
- centrosome cycle
- tight junction assembly
- regulation of microtubule polymerization
- regulation of glycolysis
- positive regulation of cell-substrate adhesion
- protein folding
- positive regulation of microtubule polymerization
- maintenance of protein location in nucleus
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- lateral plasma membrane
- Golgi apparatus
- nucleolus
- nucleoplasm
- nucleus
- mitochondrial intermembrane space
- centrosome
- focal adhesion
- mitochondrial matrix
- cytoplasm
- mitochondrion
- cilium
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding