Polr2c Gene Summary [Mouse]
Predicted to enable DNA binding activity and protein dimerization activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in 1st branchial arch; alimentary system; limb; and sensory organ. Orthologous to human POLR2C (RNA polymerase II subunit C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polr2c |
| Official Name | polymerase (RNA) II (DNA directed) polypeptide C [Source:MGI Symbol;Acc:MGI:109299] |
| Ensembl ID | ENSMUSG00000031783 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) II (DNA directed) polypeptide C |
| Synonyms | hRPB33, hsRPB3, mRBP31, polymerase (RNA) II (DNA directed) polypeptide C, RNA polymerase II subunit C, RPB3, RPB31, Rpo2-3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr2c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerases D
- DNA-directed RNA polymerase
- RNA polymerase Rpb3/Rpb11 dimerization domain
- enzyme
- protein binding
- RNA polymerase Rpb3/RpoA insert domain
- RPB11 and RPB3 subunits of RNA polymerase
Pathways
Biological processes and signaling networks where the Polr2c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- familial premature ovarian failure
- infection by HIV-1
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- MYOG
role in cell
- survival
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr2c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
- DNA-directed RNA polymerase II, core complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA polymerase II activity
- protein binding
- protein dimerization activity