POLR2C
POLR2C Gene Summary
This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit, POLR2J. These two subunits form a core subassembly unit of the polymerase. A pseudogene has been identified on chromosome 21. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | POLR2C |
| Official Name | RNA polymerase II subunit C [Source:HGNC Symbol;Acc:HGNC:9189] |
| Ensembl ID | ENSG00000102978 |
| Bio databases IDs | |
| Aliases | RNA polymerase II subunit C, RNA polymerase II subunit 3 |
| Synonyms | hRPB33,hsRPB3,mRBP31,polymerase (RNA) II (DNA directed) polypeptide C,RNA polymerase II subunit C,RPB3,RPB31,Rpo2-3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerases D
- DNA-directed RNA polymerase
- RNA polymerase Rpb3/Rpb11 dimerization domain
- enzyme
- protein binding
- RNA polymerase Rpb3/RpoA insert domain
- RPB11 and RPB3 subunits of RNA polymerase
Pathways
Biological processes and signaling networks where the POLR2C gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- KDR
- XPO1
- ESR2
- SNRPB
- CAMK2D
- CCT7
- POLR1D
- CDC73
- OPTN
- PSMC1
disease
- familial premature ovarian failure
- infection by HIV-1
regulated by
- NEF
- SUMO2
- APP
- MLN7243
- CD3 (complex)
- curcumin
- nicotine
- apigenin
- NFKBIA
- EGR2
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
- MYOG
role in cell
- survival
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the POLR2C gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- transcription from RNA polymerase II promoter
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
- DNA-directed RNA polymerase II, core complex
MOLECULAR FUNCTION
What the gene product does at the molecular level
- DNA binding
- RNA polymerase II activity
- protein binding
- protein dimerization activity